You may have been thinking of cross-reactivity between penicillins and chemically related beta-lactam compounds, such as the cephalosporins. Thus, the Septra prescription would have been safe to administer to the patient with documented penicillin allergy.
#PENICILLIN CROSS REACTIVITY SKIN#
1 more than 95 of these reported allergies do not have an immunoglobulin e (ige)-mediated or immediate hypersensitivity response when skin testing is done. Sulfonamides are a distinctly different class of antibiotics than the penicillins, and there is no known cross-reactivity between the 2. penicillin allergy is reported in approximately 8 to 15 of the general public. Septra is the registered trade name for cotrimoxazole, a sulfonamide combination product of trimethoprim/sulfamethoxazole. Non-IgE-mediated hypersensitivity reactions. The rate of cross-reactivity between a penicillin and cephalosporin due to antibody recognition is <2 in those who are skin test positive <1 in patients not skin tested. Whenever a patient reports a history of drug allergy, the healthcare provider must be vigilant in determining whether the reported reaction was truly an allergic reaction, and if so, must safeguard the patient against administration of drugs in the same drug class or structurally similar drug classes, for fear of cross-reactivity. The cross-reactivity between B-lactams with IgE-mediated hypersensitivity may be predicted by similarities of R-side chains.
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